Determination of streptococcus pneumonia Resistant to Penicillin and Ceftriaxone by E-test method
Trauma Monthly: January 31, 2008, 12 (4); e93364
January 31, 2007
Article Type: Research Article
May 11, 2019
January 31, 2007
H, Fasihi Dastjerdi
M, Mobasheri zadeh
S, et al. Determination of streptococcus pneumonia Resistant to Penicillin and Ceftriaxone by E-test method,
Objective. Material and Methods. Results. This study was performed on 98 people with age range between 5 to 10 years. Among patient, 47% are female and 53% are male. The studied samples are 55% from throat of healthy carrier, 20% from CSF,16.5% from blood, 3% from pleural fluid, 3% from ear (patients with otitis), 1% (1 person) from abscess and 1% (1 person) from wound. Separated Pneumococcus showed about 30% sensitivity to penicillin whereas MIC of ceftriaxone for cases other than meningitis is about 90% sensitivity and this MIC for meningitis considering lesser penetration of the drug in CNS, is 81.5% sensitivity.
Conclusion. Penicillin is not an effective drug for coverage of Pneumococcus even in children, but considering effectiveness of ceftriaxone, this drug alone is sufficient in cases suspicious of Pneumococcus at early presentation.
This cross-sectional prospective study was performed in 1385 on 98 streptococcus pneumonia samples separated from clinical samples of patients presenting to Al-Zahra Hospital, and then MIC (Minimal Inhibitory Concentration) of antibiotics ceftriaxone and penicillin on the organisms was determined using E-Test method. Quality control was done using Pneumococcus ATCC 49619. After editing and entering in to computer, data were analyzed using SPSS-13 and WHONET-5. Pneumococcus is among most common gram-positive bacteria causing infection in human and unfortunately, resistance of Pneumococcus is increasing daily like other bacteria. Considering that no useful research regarding rate of resistance of Pneumococcus against ceftriaxone has been done by E-test method (at least in Isfahan province ), the above study can be a base for future studies about determination of increase or decrease in Pneumococcus resistance rate.
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