Investigation of the frequency of gram negative nosocomial infections and Evaluation of Antimicrobial Resistance Patterns by E-test and Disk diffusion methods in Sina Hospital
Trauma Monthly: 13 (1); 51-57 Article Type: Research Article
M, Zia Bashar Hagh
N. Investigation of the frequency of gram negative nosocomial infections and Evaluation of Antimicrobial Resistance Patterns by E-test and Disk diffusion methods in Sina Hospital,
Online ahead of Print
This cross sectional study has been performed on 180 samples which were taken from patients who suffered from nosocomial infections in Sina hospital, during the years 2004-2005. In this study, the susceptibility of four micro-organisms including Pseudomonas aeruginosa, Acinetobacter, Klebsiella and Ecoli to the antimicrobial agents including Imipenem, Cefepime, Ceftazidime, Ciprofloxacin and Ceftriaxone were determined by E-test and Disk diffusion methods.
The most common sample and microorganism were blood (n=66, 36.7%) and Klebsiella (%46.7) respectively. The most common nosocomial infections were unknown septicemia (%22.8), pneumonia (%22.2) and UTI (%18.3). Imipenem was found the most active also effective agent (%83.70). Comparison between results from E-test and disk diffusion methods, for determining of susceptibility and resistance of all microorganisms to all antibiotics, showed that both methods are approximately similar. In this study, high resistance to the antimicrobial agents was seen by comparison with other studies. According to increase in the rate of antimicrobial resistance, especially in the third generation of Cephalosporins, it is necessary to be more careful about prescribing empirical drugs.
Antimicrobial resistance; Gram-negative bacilli; Nosocomial infection; Disk diffusion; E-test method
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