Evaluation of percents of T helper and T cytotoxic in the peripheral blood of chemical injured veterans exposed to Sulfur Mustard and their correlation with pruritus
Trauma Monthly: 13 (2); 133-139 Article Type: Research Article
M, Naghi Zadeh
M, et al. Evaluation of percents of T helper and T cytotoxic in the peripheral blood of chemical injured veterans exposed to Sulfur Mustard and their correlation with pruritus,
Online ahead of Print
Introduction: Sulfur mustard is one of the chemical agents’ causes long-term dermatologic complications and pruritic lesions in exposed veterans. This chemical agent also can affect immunologic system of exposed persons and compromised it. This survey was design to evaluate impact of sulfur mustard on T helper and T cytotoxic percent and its correlation with pruritus. Material & Methods: At this cohort 36 sulfur mustard exposed male veterans after 20 years and 26 male patients with pruritic lesions without sulfur mustard exposure were enrolled randomly. Evaluation of itching was done with pruritus score. Assessment of T helper and T cytotoxic were done with fluocytometric monoclonal antibody antiCD3, anti CD4 and anti CD8. Results:There are no significant differences between means of T helper and T cytotoxic at both groups (P=0.925, P=0.816).There is no correlation between severity of pruritus and CD4/CD8 ratio at both groups (P=0/920, P=0.977). Conclusion:CD markers associated with T helper and T cytotoxic lymphocyte in chemical injured veterans exposed to sulfur mustard after 20 years that have dermatologic complications is similar to patients with non chemical pruritus and percent and proportion of CD4 and CD8 have no impact on severity of pruritus.
chemical injured veterans; sulfur mustard; T helper cells; T cytotoxic cells; pruritus score
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