Study of the relationship between serum ferritin levels and coronary artery disease
Trauma Monthly: 13 (3); 245-252 Article Type: Research Article
M. Study of the relationship between serum ferritin levels and coronary artery disease,
Online ahead of Print
Objective. Epidemiological studies have indicated an association between higher body iron stores and coronary artery diseases. It is believed that inflammation and oxidation are important mechanisms involved in the complex and pathological process of atherogenesis. Free radical production is catalyzed and accelerated in the presence of iron that these agents increasing lipid peroxidation special LDL. The determination of plasma ferritin levels is a convenient iron balance assessment method. The purpose of this study was to define the correlation of ferritin levels with severity and extent of coronary artery atherosclerosis. Material and Methods. In this cross-sectional study that done from April to June 2008 in Shahid Chamran and Sina hospitals in Isfahan, 169 consecutive patients that containing 139 male (82.2%) and 30 female (17.8%) underwent previously indicated coronary artery angiography were selected. Results. Study of Gensini Score (G.S) were revealed that ferritin was significantly correlated with severity and extension of atherosclerosis in the men (p=0.04). Also, there was statistically significant between the diabetes history, FBS>140 mg/dl, mean of systolic and diastolic hypertension and cigarette smoking with G.S (p<0.05). But there no was significant difference between severity and extension of atherosclerosis and ferritin levels with major risk factors such as hypertension, hypercholesterolemia, hypertriglyceridemia, familial coronary diseases history and BMI (p>0.05). Results of this study confirmed a strong correlation of serum ferritin levels with severity and extension of coronary atherosclerosis. However, regarding to the results of this study in men it could have a role in the promotion and augmentation of coronary atherosclerosis, suggestion that ferritin could be a comparable index in patients with ischemic heart disease. Conclusion.
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