Evaluation of Ethanolic Extracts of Tagetes Minuta against Candida Albicans, Susceptible and Resistance to Fluconazole
Trauma Monthly: 12 (1); 21-28 Article Type: Research Article
January 1, 2007
January 1, 2007
H. Evaluation of Ethanolic Extracts of Tagetes Minuta against Candida Albicans, Susceptible and Resistance to Fluconazole,
Online ahead of Print
Introduction. Evaluation of anti-Candidal effects of Tagetes Minuta extract against Candida Albicans resistance and sensitive to Fluconazole. Material and Methods. Approaching to this goal obtained by collecting the root plant in bloom stage, washing them and extracting with 70% ethanolic by maceration. The macerate was filtered and concentrated at 40 ° c. Yeasts resistance and sensitive to Fluconazole in suboroud dextrose broth were pured in 96 well micro test tray and exposed to Tagetes Minuta extracts. Results. Results of this study showed that antifungal extract has effect against C. Albicans resistance and sensitive to Fluconazole. The minimal inhibitory concentration of Tagetes Minuta determined in the range of 69 μ g/ml for all tested C. Albicans. In general the results obtained in this study indicated that T. Minuta has potential effects on for inhibition of C. Albicans. Conclusion. In this study, yeast extract of T. Minuta has more effect on C. Albicans resistance to Fluconazole compared with the susceptible ones. Wide range use antifungal agents especially azole compounds in treatment of candidiasis has resulted in fungal resistance in Candida. Thus it is necessary to use antifungal susceptibility tests before selecting a suitable drug for infections which can result in the decrease in secondary drug resistance and better manipulation of treatment protocols. According to the results of this test and antifungal activity on C. Albicans isolates it seems that plant extracts are good antifungal sources in control of human diseases.
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