Formulation of Spironolactone Cream and Comparative Evaluation of Oral and Local Spironolactone Efficacy in Management of Hirsutism
Trauma Monthly: 11 (3); 235-240 Article Type: Research Article
January 1, 2006
January 1, 2006
S. Formulation of Spironolactone Cream and Comparative Evaluation of Oral and Local Spironolactone Efficacy in Management of Hirsutism,
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Aims. The aim of this study was evaluation the formulation of spironolactone cream and comparative evaluation of oral and local spironolactone efficacy in management of hirsutism. Methods. 77 patients with hirsutism were randomized to use spironolactone cream (n=39) or spironolactone tablets (n=38). Before beginning the study, hirsutism scores of both groups were measured and no significant difference was observed between them. All the patients used their medications for 7 months and were visited by a dermatologist monthly. After the course of treatment, the hirsutism score was measured for all of them and compared with the base score at the beginning of the treatment. Results. Among tablet-receiving patients, in 15.8% hirsutism score significantly decreased (p<0.05). In 44.7% there was a non-significant decrease in hirsutism score and the scores in 39.5% of them didn’t change. In contrast, 55.8% of patients used spironolactone cream, had significant decrease in their hirsutism score and in the rest of the patients of this group, although the scores decreased, it was not significant. In cream-receiving patients, no one experienced side effects while in patients took oral spironolactone, drug adverse effects including headache, nausea and menstrual dysfunction were seen in 40% of cases. Conclusion. Using spironolactone cream compared with tablet was associated with significant decrease of hirsutism score and less side effects. As hirsutism needs a long term therapy, it seems that local therapy with cream is much better in treating hirsute patients.
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