Evaluation of the Use of Oral Premeditation With Clonidine in Order to Reduce the Dose of Anesthetic Drugs Inpatients Requiring Deliberate Hypotemtion
Trauma Monthly: 11 (2); 191-197 Article Type: Research Article
S. Evaluation of the Use of Oral Premeditation With Clonidine in Order to Reduce the Dose of Anesthetic Drugs Inpatients Requiring Deliberate Hypotemtion,
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Aims. Due to need for providing bloodless surgical field in patients undergoing middle ear, nose and sinus endoscopy with deliberate hypotention, this study in order to decrease the dose of anesthetic drugs is performed. Methods. In this double blind clinical trial study, 60 patients, 15 to 40 years old, ASA class I undergoing ear, sinus, jaw and sinus endoscopy, were randomly separated into two equal groups. The first (case) group received 0.2 mg oral clonidine and the second group received a placebo 90 minutes before surgery. Vital signs and Ramsay sedation score were recorded preoperatively in the ward and upon entrance to the operating room. Before induction of anesthesia, the patients received 3-5 ml/kg normal saline solution and fentanyl 1 μ g/kg up to 3 μ g/kg to achieve a Ramsay score of 3. Anesthesia was induced with sodium thiopental 3 mg/kg in titrated doses, and tracheal intubation was done with the aid of atracurium 0.5 mg/kg. Anesthesia was maintained with halothane in combination with N 2O 50% in O 2. The dose of drugs for induction and maintenance of anesthesia to achieve systolic blood pressure of 80-90 mmHg, adverse events, awake extubation time and recovery time were recorded. The results were compared using SPSS software and t test. P<0.05 was considered significant. Results. According to our results, the mean doses of fentanyle, thiopental, midazolam and mean percentage of halothan to achieve systolic blood pressure of 80-90 mmHg in the clonidine group was less than those in the placebo group (P<0.05). The extubathion time and recovery time in the clonidine group was significantly shorter than those in the control group. Conclusion. The use of oral premedication of clonidine in selected patients requiring deliberate hypotention to improve operative field, in order to reduce the dose of anesthetic drugs and reduction of extubation and recovery time is useful and recommended.
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