Relation Between Protamine1/Protamine 2 Ratio with Fertilization and Embryo Quality and Developmental Rate in ICSI and IVF Patients
Trauma Monthly: 11 (1); 13-21 Article Type: Research Article
M H, Razavi
H, et al. Relation Between Protamine1/Protamine 2 Ratio with Fertilization and Embryo Quality and Developmental Rate in ICSI and IVF Patients,
Online ahead of Print
Objective: To evaluate the effect of P1/P2 ratio on fertilization and embryo quality and developmental rate in intra cytoplasmic sperm injection (ICSI) and in vitro fertilization (IVF) patients. Material and Methods: During this study P1/P2 ratio of 71 patients referring for IVF and ICSI were evaluated by protein extraction, gel-electrophoresis and western blot. Results: Increase in P1/P2 results in a reduction in fertilization rate and decrease in embryo quality in ICSI patients. Conclusion: It can be concluded that altered P1/P2 ratio affects fertilization rate and embryo quality, which subsequently effect implantation and pregnancy outcome.
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