Study the therapeutic effect of Colchicine on delayed pulmonary injury of sulfur mustard in animal model
Trauma Monthly: 13 (2); 125-132 Article Type: Research Article
L. Study the therapeutic effect of Colchicine on delayed pulmonary injury of sulfur mustard in animal model,
Online ahead of Print
Introduction:Among late disorders of mustard gas, respiratory problems especially chronic bronchitis and pulmonary fibrosis are the greatest causes of long-term disability. Colchicine has anti-inflammatory effects and also indication of usage in pulmonary fibrosis. According to these and note to the effect of oxidative stress in pathogenesis of chronic bronchitis and pulmonary fibrosis, the therapeutic effects of Cochicine and the role of oxidative stress in its mechanism have been studied.
Material and Methods:One group of mice that had inhaled SM one month ego was treated by Colchicine. After sacrificing and sampling, biochemical indexes of chronic inflammation and pulmonary fibrosis of experimental group, compared with positive and negative control groups. Results. significant decrease was seen in alveolar space percentage, serum vitamin C, Catalase and increase in hydroxylproline concentration, lymphocyte infiltration and serum H 2O 2 in positive control group in comparison with negative control. Vitamin C and Catalase increase and hydroxylproline concentration, lymphocyte infiltration and serum H 2O 2 decrease in experimental group in comparison with positive control group. Conclusion. Colchicine has therapeutic effects on delayed lung complications of SM injury and diminishing the oxidative stress can be one of mechanisms of this drugs.
© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.