Importance of Using Random Urinary Protein to Creatinine Ratio for Proteinuria in Patients Suspected to Preeclampsia
Trauma Monthly: 11 (3); 293-298 Article Type: Research Article
January 1, 2006
January 1, 2006
M. Importance of Using Random Urinary Protein to Creatinine Ratio for Proteinuria in Patients Suspected to Preeclampsia,
Online ahead of Print
Introduction. Considering the pitfalls of measuring urinary protein for detecting proteinuria & importance of proteinuria in pregnant women, is necessary to recognizing method that is both faster and easier. One of these methods is using Pr/Cr Ratio is urinary sample that its validity is controversial in different studies. In this study we tried to compare between Pr/Cr ratios in random urinary sample with a standard method that is now available for pregnant women suspected to preeclampsia. Material and Methods. In a "process research" study that was done in Bagiyatallah hospital in Tehran during 3 years on 121 pregnant women that their gestational ages was above 24 weeks and they were suspected to preeclampsia . In this study two methods of measuring urinary random Pr/Cr ratio of collected of 24 hrs urine as a standard method was performed in patients. Sensitivity & specificity of this test for measuring proteinuria was calculated in different levels. Results. 50% of 121 patients contributed in studies had significant proteinuria in 24 hrs urinary sample. Results showed that Pr/Cr ratio levels below 0.12 concluded apparent proteinuria and best level for distinguishing proteinuria was 0.19 and above that had (90%) Sensitivity and 70% specificity. All false negative cases had below 400 mg Pr in 24 hrs collected urine. 15 cases of 18 false positive had 250-300 mg level. Correlative coefficient of study was 0.82 (P<0.001). Conclusion. In this study there was a strong relation between Pr/Cr & preeclaupsia. Best level for predicting significant proteinuria was above 0.19. It assumes with wider studies determining random urinary Cr/Pr ratio is a faster & simpler way & is a good alternative for 24hrs urine collection.
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