The Study of the Wound Potential Changes During the Healing Process and its Relation to the Wound Size
Trauma Monthly: 11 (3); 241-250 Article Type: Research Article
January 1, 2006
January 1, 2006
V. The Study of the Wound Potential Changes During the Healing Process and its Relation to the Wound Size,
Online ahead of Print
Objrctive. The objectives of this research were to study the changes of electrical potential of a full thickness skin incision by a non-invasive method during the three weeks of healing process and to determine its relationship with the wound surface area. Material and Methods. 13 male albino guinea pigs, weighing 350-400 grams, were used. A full thickness skin incision, 2.5 cm of length, was made on the right side of spinal column at a distance of 1 cm to spinous processes. The differential potential of the wound site was measured before, immediately after the injury and also through the healing process until the 21 st day. The wound surface area was measured during the healing process too. Results. Before wounding, the electrical potential of the intact skin was – 0.05 ± 1.75 mv. Immediately after the injury, potential reached to 2.66 ± 1.07 mv and at the next day reached to the peak value of 6.36 ± 1.65 mv. Afterwards, the potential of the wound site began to decrease. A significant correlation, R 2 = 0.86, was found between the wound potential changes and wound surface area. Conclusion. The closure of the wound surface occurs faster than the wound potential returns to normal value of the intact skin. It appears that the return of wound potential to the level of before injury needs return of skin structure and function to the natural level. According to the present study, the measuring of wound potential by this non-invasive method can be used as an objective and practical method for evaluation of healing process, especially in human studies.
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