Anti-diabetic and endothelium-dependent effect of Allium schoenoprasum L. feeding on contractile and relaxatory response of thoracic aorta of diabetic rats
Trauma Monthly: 14 (2); 63-70 Article Type: Research Article
M, Balouchnejad Mojarrad
T, Roghani Dehkordi
F. Anti-diabetic and endothelium-dependent effect of Allium schoenoprasum L. feeding on contractile and relaxatory response of thoracic aorta of diabetic rats,
Online ahead of Print
Aims:D iabetes mellitus is accompanied with higher incidence of cardiovascular disorders. There is some evidence on antidiabetic potential of Allium schoenoprasum L. (AS). Thus, t he endothelium-dependent effect of oral administration of AA for 8 weeks on contractile and relaxatory response of thoracic aorta from diabetic rats investigated.
Materials & Methods: Male Wistar rats were divided into 5 "control", " AS-treated control", "diabetic", "AS-treated diabetic" and "glibenclamide-treated diabetic" groups. T reated groups received AS-mixed pelleted food at a weight ratio of 3%. Body weight and serum glucose level were measured before the study and at weeks 4 and 8. At the end of study, contractile reactivity of thoracic aortic rings to KCl and phenylephrine and relaxatory response to acetylcholine and sodium nitroprusside were determined using isolated tissue setup.
Results: Serum glucose level significantly decreased in AS-treated diabetic group versus untreated diabetics (p<0.05). In addition, endothelium-intact AS-treated diabetic group showed a significantly lower contraction to KCl and phenylephrine (p<0.05) as compared to diabetic group and endothelium removal abolished this response. Meanwhile, relaxation response of endothelium-intact rings to acetylcholine was significantly higher in AS-treated diabetic group as compared to diabetics (p<0.05). In addition, there were no significant changes amongst the groups regarding relaxatory response to sodium nitroprusside.
Conclusion: Chronic oral administration of AS through affecting endothelial-related agents can decrease contractile response and enhance relaxatory response in aortic tissue of diabetic rat and this may be beneficial in prevention of long-term vascular complications of diabetes.
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