Efficacy of cone biopsy of uterine cervix during frozen sectionin evaluation of cervical intraepithelial neoplasia
Trauma Monthly: 15 (1); 49-53 Article Type: Research Article
V. Efficacy of cone biopsy of uterine cervix during frozen sectionin evaluation of cervical intraepithelial neoplasia,
Online ahead of Print
Aims: To determine the role of frozen section examination (FSE) of the cone specimen in the evaluation of the resection margin status and to rule out invasion in patients with high-grade cervical intraepithelial neoplasia.
Methods: Twenty patients of High grade intraepithelial neoplasia, that underwent conization biopsy and frozen section examination were done for them, were studied cross sectional from March 2008 until September 2009.The results of permanent paraffin sections were compared with FSE.
Results: among these twenty cases, 15 of theme (75%) had the same results in frozen and permanent sections of cone biopsy specimen . Among these latest 5 patient, 2 had higher grade of CIN in frozen section, 2 had lower grade and one was considered the same because of CIN1 in FSE was normal in permanent sections. Among these differences only one case was found in which the FSE result was CIN3 and permanent sections was invasive carcinoma had clinical importance and considered significant. Although The Paired Sample T-test showed no significant difference between two groups of frozen and permanent section results (P-value=0.716,CI=95%)
Conclusions: Frozen section evaluation of cervical cone biopsy specimens in patients given a diagnosis of CIN 3 is accurate,efficient, and cost-effective. because of the importance of even one case missing there should be more researches in this controversial subject.
© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.