Trauma Monthly

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Comparing the Effect of Hirudoid on Random Skin Flap Survival in Rats Based on Different Application Times

Babak Nikoumaram 1 , Mohammad Javad Fatemi 2 , * , Shahrzad Taghavi 3 , Mohsen Saberi Isfeedvajani 4 , Zeinab Nematzadeh 3 , Bahareh Salehi 3 and Shirin Araghi 5
Authors Information
1 Department of Plastic and Reconstructive Surgery, Tehran Azad Medical University, Tehran, Iran
2 Department of Plastic and Reconstructive Surgery, Burn Research Center, Iran University of Medical Sciences, Tehran, Iran
3 Department of General Physician, Burn Research Center, Iran University of Medical Sciences, Tehran, Iran
4 Medicine, Quran and Hadith Research Center and Department of Community Medicine, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
5 Department of Nursing, Burn Research Center, Iran University of Medical Sciences, Tehran, Iran
Article information
  • Trauma Monthly: November 2017, 22 (6); e38753
  • Published Online: December 11, 2016
  • Article Type: Research Article
  • Received: April 26, 2016
  • Revised: November 9, 2016
  • Accepted: November 29, 2016
  • DOI: 10.5812/traumamon.38753

To Cite: Nikoumaram B, Fatemi M J, Taghavi S, Saberi Isfeedvajani M, Nematzadeh Z, et al. Comparing the Effect of Hirudoid on Random Skin Flap Survival in Rats Based on Different Application Times, Trauma Mon. 2017 ; 22(6):e38753. doi: 10.5812/traumamon.38753.

Copyright © 2016, Trauma Monthly. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Forootan S, Nikoumaram B, Fatemi M, Nojomi M, Akbari H, Hasani M. The Effect of aspirin, dexamethasone and their combination on rndom skin flap survival in rats at Hazrat Fateme educational and research center. Iran J Surg. 2009; 17(2): 10-8
  • 2. Hart K, Baur D, Hodam J, Lesoon-Wood L, Parham M, Keith K, et al. Short- and long-term effects of sildenafil on skin flap survival in rats. Laryngoscope. 2006; 116(4): 522-8[DOI][PubMed]
  • 3. Livaoglu M, Kerimoglu S, Sonmez B, Livaoglu A, Karacal N. The effect of Hirudoid on random skin-flap survival in rats. J Plast Reconstr Aesthet Surg. 2010; 63(6): 1047-51[DOI][PubMed]
  • 4. Gulmez SE, Serel S, Uluc A, Can Z, Ergun H. Dipyrone increases the blood flow of arterial dorsal skin flaps. Aesthetic Plast Surg. 2008; 32(5): 766-70[DOI][PubMed]
  • 5. Beheshtian A, Demehri S, Kiumehr S, Salmasi AH, Nezami BG, Rahimpour S, et al. ATP-sensitive potassium channels mediate the anti-ischemic properties of ischemic and pharmacologic preconditioning in rat random-pattern skin flap. Ann Plast Surg. 2006; 57(1): 94-9[DOI][PubMed]
  • 6. Huemer GM, Wechselberger G, Otto-Schoeller A, Gurunluoglu R, Piza-Katzer H, Schoeller T. Improved dorsal random-pattern skin flap survival in rats with a topically applied combination of nonivamide and nicoboxil. Plast Reconstr Surg. 2003; 111(3): 1207-11[DOI][PubMed]
  • 7. Tsai JW, Ayubi FS, Hart KL, Baur DA, Parham MA, Moon JK, et al. Evaluation of the effect of sildenafil and vascular endothelium growth factor combination treatment on skin flap survival in rats. Aesthetic Plast Surg. 2008; 32(4): 624-31[DOI][PubMed]
  • 8. Torkvist L, Lundeberg T, Thorlacius H, Larsson J, Lofberg R, Lofgren O, et al. Effects of environmental stress on tissue survival and neutrophil recruitment in surgical skin flaps in relation to plasma corticosterone levels in the rat. Inflamm Res. 1997; 46(6): 199-202[DOI][PubMed]
  • 9. Ghavami A, Nutt MP, Hardy SP. Heat shock protein and high-dose aspirin: effects on random skin flap survival in a rat model. Ann Plast Surg. 2002; 48(1): 60-7[DOI][PubMed]
  • 10. Davis RE, Wachholz JH, Jassir D, Perlyn CA, Agrama MH. Comparison of topical anti-ischemic agents in the salvage of failing random-pattern skin flaps in rats. Arch Facial Plast Surg. 1999; 1(1): 27-32[DOI][PubMed]
  • 11. McFarlane RM, Deyoung G, Henry RA. The Design of a Pedicle Flap in the Rat to Study Necrosis and Its Prevention. Plast Reconstr Surg. 1965; 35: 177-82[DOI][PubMed]
  • 12. Harada N, Okajima K, Kohmura H, Uchiba M, Tomita T. Danaparoid sodium reduces ischemia/reperfusion-induced liver injury in rats by attenuating inflammatory responses. Thromb Haemost. 2007; 97(1): 81-7[PubMed]
  • 13. Gorog P, Raake W. Antithrombotic effect of a mucopolysaccharide polysulfate after systemic, topical and percutaneous application. Arzneimittelforschung. 1987; 37(3): 342-5[PubMed]
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