Trauma Monthly

Published by: Kowsar

Effect of Modafinil Administration on the Level of Consciousness in Patients with Brain Injuries of Moderate Severity

Omid Moradi Moghadam 1 , Nima Nematollahi 2 , Ebadallah Shiri Malek Abad 3 , Valiolah Hasani 2 , Alireza Tabibkhooei 2 , Mehrdad Sheikhvatan 2 and Mohammad Niakan Lahiji 1 , *
Authors Information
1 Anesthesiology and Critical Care Department of Iran University Medical Sciences, Rasool-e-Akram Complex Hospital, Trauma and Injury Research Center, Iran University of Medical Sciences, Tehran, Iran
2 Iran University of Medical Sciences, Tehran, Iran
3 AJA University of Medical Sciences, Tehran, Iran
Article information
  • Trauma Monthly: 24 (1); e61505
  • Published Online: July 23, 2018
  • Article Type: Research Article
  • Received: September 9, 2017
  • Revised: December 24, 2017
  • Accepted: January 9, 2018
  • DOI: 10.5812/traumamon.61505

To Cite: Moradi Moghadam O, Nematollahi N, Shiri Malek Abad E, Hasani V, Tabibkhooei A, et al. Effect of Modafinil Administration on the Level of Consciousness in Patients with Brain Injuries of Moderate Severity, Trauma Mon. Online ahead of Print ; 24(1):e61505. doi: 10.5812/traumamon.61505.

Abstract
Copyright © 2018, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
References
  • 1. Zeiler KJ, Zeiler FA. Social Determinants of Traumatic Brain Injury in the North American Indigenous Population: A Review. Can J Neurol Sci. 2017;44(5):525-31. doi: 10.1017/cjn.2017.49. [PubMed: 28535822].
  • 2. Boniface R, Lugazia ER, Ntungi AM, Kiloloma O. Management and outcome of traumatic brain injury patients at Muhimbili Orthopaedic Institute Dar es Salaam, Tanzania. Pan Afr Med J. 2017;26:140. doi: 10.11604/pamj.2017.26.140.10345. [PubMed: 28533863]. [PubMed Central: PMC5429442].
  • 3. Swanson TM, Isaacson BM, Cyborski CM, French LM, Tsao JW, Pasquina PF. Traumatic Brain Injury Incidence, Clinical Overview, and Policies in the US Military Health System Since 2000. Public Health Rep. 2017;132(2):251-9. doi: 10.1177/0033354916687748. [PubMed: 28135424]. [PubMed Central: PMC5349478].
  • 4. Bergersen K, Halvorsen JO, Tryti EA, Taylor SI, Olsen A. A systematic literature review of psychotherapeutic treatment of prolonged symptoms after mild traumatic brain injury. Brain Inj. 2017;31(3):279-89. doi: 10.1080/02699052.2016.1255779. [PubMed: 28125305].
  • 5. Kaiser PR, Valko PO, Werth E, Thomann J, Meier J, Stocker R, et al. Modafinil ameliorates excessive daytime sleepiness after traumatic brain injury. Neurology. 2010;75(20):1780-5. doi: 10.1212/WNL.0b013e3181fd62a2. [PubMed: 21079179].
  • 6. Crompton EM, Lubomirova I, Cotlarciuc I, Han TS, Sharma SD, Sharma P. Meta-Analysis of Therapeutic Hypothermia for Traumatic Brain Injury in Adult and Pediatric Patients. Crit Care Med. 2017;45(4):575-83. doi: 10.1097/CCM.0000000000002205. [PubMed: 27941370].
  • 7. Dismuke CE, Walker RJ, Egede LE. Utilization and Cost of Health Services in Individuals With Traumatic Brain Injury. Glob J Health Sci. 2015;7(6):156-69. doi: 10.5539/gjhs.v7n6p156. [PubMed: 26153156]. [PubMed Central: PMC4803849].
  • 8. Fakharian E, Mohammadzadeh M, Behdadmehr S, Sabri HR, Mirzadeh AS, Mohammadzadeh J. Repetitive Traumatic Brain Injury in Patients From Kashan, Iran. Trauma Mon. 2016;21(4). e23869. doi: 10.5812/traumamon.23869. [PubMed: 28180123]. [PubMed Central: PMC5282941].
  • 9. Kavosi Z, Jafari A, Hatam N, Enaami M. The economic burden of traumatic brain injury due to fatal traffic accidents in shahid rajaei trauma hospital, shiraz, iran. Arch Trauma Res. 2015;4(1). e22594. doi: 10.5812/atr.22594. [PubMed: 25834791]. [PubMed Central: PMC4377539].
  • 10. Koponen S, Taiminen T, Portin R, Himanen L, Isoniemi H, Heinonen H, et al. Axis I and II psychiatric disorders after traumatic brain injury: a 30-year follow-up study. Am J Psychiatry. 2002;159(8):1315-21. doi: 10.1176/appi.ajp.159.8.1315. [PubMed: 12153823].
  • 11. Himanen L, Portin R, Isoniemi H, Helenius H, Kurki T, Tenovuo O. Longitudinal cognitive changes in traumatic brain injury: a 30-year follow-up study. Neurology. 2006;66(2):187-92. doi: 10.1212/01.wnl.0000194264.60150.d3. [PubMed: 16434651].
  • 12. Lippert-Gruner M, Kuchta J, Hellmich M, Klug N. Neurobehavioural deficits after severe traumatic brain injury (TBI). Brain Inj. 2006;20(6):569-74. doi: 10.1080/02699050600664467. [PubMed: 16754282].
  • 13. Baumann CR, Werth E, Stocker R, Ludwig S, Bassetti CL. Sleep-wake disturbances 6 months after traumatic brain injury: a prospective study. Brain. 2007;130(Pt 7):1873-83. doi: 10.1093/brain/awm109. [PubMed: 17584779].
  • 14. Cheng K, Bassil R, Carandang R, Hall W, Muehlschlegel S. The Estimated Verbal GCS Subscore in Intubated Traumatic Brain Injury Patients: Is it Really Better? J Neurotrauma. 2017;34(8):1603-9. doi: 10.1089/neu.2016.4657. [PubMed: 27774844]. [PubMed Central: PMC5397225].
  • 15. Kasprowicz M, Burzynska M, Melcer T, Kubler A. A comparison of the Full Outline of UnResponsiveness (FOUR) score and Glasgow Coma Score (GCS) in predictive modelling in traumatic brain injury. Br J Neurosurg. 2016;30(2):211-20. doi: 10.3109/02688697.2016.1161173. [PubMed: 27001246].
  • 16. Kehoe A, Smith JE, Bouamra O, Edwards A, Yates D, Lecky F. Older patients with traumatic brain injury present with a higher GCS score than younger patients for a given severity of injury. Emerg Med J. 2016;33(6):381-5. doi: 10.1136/emermed-2015-205180. [PubMed: 26825613].
  • 17. Ward Fuller G, Hernandez M, Pallot D, Lecky F, Stevenson M, Gabbe B. Health State Preference Weights for the Glasgow Outcome Scale Following Traumatic Brain Injury: A Systematic Review and Mapping Study. Value Health. 2017;20(1):141-51. doi: 10.1016/j.jval.2016.09.2398. [PubMed: 28212955]. [PubMed Central: PMC5339086].
  • 18. Saika A, Bansal S, Philip M, Devi BI, Shukla DP. Prognostic value of FOUR and GCS scores in determining mortality in patients with traumatic brain injury. Acta Neurochir (Wien). 2015;157(8):1323-8. doi: 10.1007/s00701-015-2469-6. [PubMed: 26077394].
  • 19. McNett M, Amato S, Gianakis A, Grimm D, Philippbar SA, Belle J, et al. The FOUR score and GCS as predictors of outcome after traumatic brain injury. Neurocrit Care. 2014;21(1):52-7. doi: 10.1007/s12028-013-9947-6. [PubMed: 24408147].
  • 20. Wisor JP, Eriksson KS. Dopaminergic-adrenergic interactions in the wake promoting mechanism of modafinil. Neuroscience. 2005;132(4):1027-34. doi: 10.1016/j.neuroscience.2005.02.003. [PubMed: 15857707].
  • 21. Prasuna PL, Sudhakar TP. Impact of Modafinil Add-on with Atypical Anti-psychotics on Excessive Daytime Drowsiness. Indian J Psychol Med. 2015;37(4):388-92. doi: 10.4103/0253-7176.168561. [PubMed: 26702168]. [PubMed Central: PMC4676202].
  • 22. Silveira MG, Gossard AA, Stahler AC, Jorgensen RA, Petz JL, Ali AH, et al. A Randomized, Placebo-Controlled Clinical Trial of Efficacy and Safety: Modafinil in the Treatment of Fatigue in Patients With Primary Biliary Cirrhosis. Am J Ther. 2017;24(2):e167-76. doi: 10.1097/MJT.0000000000000387. [PubMed: 27148676].
  • 23. McElhiney M, Rabkin J, Van Gorp W, Rabkin R. Modafinil effects on cognitive function in HIV+ patients treated for fatigue: a placebo controlled study. J Clin Exp Neuropsychol. 2010;32(5):474-80. doi: 10.1080/13803390903201769. [PubMed: 19937504]. [PubMed Central: PMC2878385].
  • 24. Spathis A, Fife K, Blackhall F, Dutton S, Bahadori R, Wharton R, et al. Modafinil for the treatment of fatigue in lung cancer: results of a placebo-controlled, double-blind, randomized trial. J Clin Oncol. 2014;32(18):1882-8. doi: 10.1200/JCO.2013.54.4346. [PubMed: 24778393].
  • 25. Jha A, Weintraub A, Allshouse A, Morey C, Cusick C, Kittelson J, et al. A randomized trial of modafinil for the treatment of fatigue and excessive daytime sleepiness in individuals with chronic traumatic brain injury. J Head Trauma Rehabil. 2008;23(1):52-63. doi: 10.1097/01.HTR.0000308721.77911.ea. [PubMed: 18219235].
  • 26. Zukkoor S. The Safety of Stimulant Medication Use in Cardiovascular and Arrhythmia Patients. American College of Cardiology; 2015. Available from: http://www.acc.org/latest-in-cardiology/articles/2015/04/28/10/06/the-safety-of-stimulant-medication-use-in-cardiovascular-and-arrhythmia-patients.
  • 27. [No Author Listed]. Archiveid Drug Label,. 2007. Available from: https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=4884.
  • 28. Stankoff B, Waubant E, Confavreux C, Edan G, Debouverie M, Rumbach L, et al. Modafinil for fatigue in MS: a randomized placebo-controlled double-blind study. Neurology. 2005;64(7):1139-43. doi: 10.1212/01.WNL.0000158272.27070.6A. [PubMed: 15824337].
  • 29. Ondo WG, Fayle R, Atassi F, Jankovic J. Modafinil for daytime somnolence in Parkinson's disease: double blind, placebo controlled parallel trial. J Neurol Neurosurg Psychiatry. 2005;76(12):1636-9. doi: 10.1136/jnnp.2005.065870. [PubMed: 16291885]. [PubMed Central: PMC1739456].
  • 30. Rammohan KW, Rosenberg JH, Lynn DJ, Blumenfeld AM, Pollak CP, Nagaraja HN. Efficacy and safety of modafinil (Provigil) for the treatment of fatigue in multiple sclerosis: a two centre phase 2 study. J Neurol Neurosurg Psychiatry. 2002;72(2):179-83. [PubMed: 11796766]. [PubMed Central: PMC1737733].
  • 31. Rezaee H, Jahani Y, Pakzad Moghaddam S, Monfared S, Ebrahimi Hooshyar A. Effect of Stimulation Program on Consciousness of Traumatic Brain Injury Patients: A Camparison of Four and Gcs Scale. Iran J Anesth Critical Care. 2015;2(2):98-104.
  • 32. Sadaka F, Patel D, Lakshmanan R. The FOUR score predicts outcome in patients after traumatic brain injury. Neurocrit Care. 2012;16(1):95-101. doi: 10.1007/s12028-011-9617-5. [PubMed: 21845490].
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