Trauma Monthly

Published by: Kowsar

Erythropoietin for Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Ali Meshkini 1 , Mohammad Meshkini 2 , * and Homayoun Sadeghi-Bazargani 3
Authors Information
1 Professor of Neurological-Surgery, Neuroscience Research Center, Department of Neurosurgery, Tabriz University of Medical Sciences, Tabriz, IR Iran
2 Student Member of Road Accidents Research Committee and Knowledge Management Unit, Tabriz University of Medical Sciences (Bio-Medicine), Tabriz, IR Iran
3 Road Traffic Injury Research Center, Department of Statistics and Epidemiology, Tabriz University of Medical Sciences, Tabriz, IR Iran
Article information
  • Trauma Monthly: September 2017, 22 (5); e37191
  • Published Online: August 2, 2016
  • Article Type: Review Article
  • Received: February 17, 2016
  • Revised: July 1, 2016
  • Accepted: July 9, 2016
  • DOI: 10.5812/traumamon.37191

To Cite: Meshkini A, Meshkini M, Sadeghi-Bazargani H. Erythropoietin for Traumatic Brain Injury: A Systematic Review and Meta-Analysis, Trauma Mon. 2017 ; 22(5):e37191. doi: 10.5812/traumamon.37191.

Copyright © 2016, Trauma Monthly. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Objectives
3. Data Sources
4. Study Selection
5. Data Extraction
6. Results
7. Conclusions
  • 1. Bennett MH, Trytko B, Jonker B. Hyperbaric oxygen therapy for the adjunctive treatment of traumatic brain injury. Cochrane Database Syst Rev. 2012; 12[DOI][PubMed]
  • 2. Schierhout G, Roberts I. Hyperventilation therapy for acute traumatic brain injury. Cochrane Database Syst Rev. 2000; (2)[DOI][PubMed]
  • 3. Thompson K, Pohlmann-Eden B, Campbell LA, Abel H. Pharmacological treatments for preventing epilepsy following traumatic head injury. Cochrane Database Syst Rev. 2015; (8)[DOI][PubMed]
  • 4. Alderson P, Roberts I. Corticosteroids for acute traumatic brain injury. Cochrane Database Syst Rev. 2005; (1)[DOI][PubMed]
  • 5. Ma J, Huang S, Qin S, You C. Progesterone for acute traumatic brain injury. Cochrane Database Syst Rev. 2012; 10[DOI][PubMed]
  • 6. Sahuquillo J, Arikan F. Decompressive craniectomy for the treatment of refractory high intracranial pressure in traumatic brain injury. Cochrane Database Syst Rev. 2006; (1)[DOI][PubMed]
  • 7. Traumatic brain injury. 2002;
  • 8. Abrishamkar S, Safavi M, Honarmand A. Effect of erythropoietin on Glasgow Coma Scale and Glasgow Outcome Sale in patient with diffuse axonal injury. J Res Med Sci. 2012; 17(1): 51-6[PubMed]
  • 9. Nichol A, French C, Little L, Haddad S, Presneill J, Arabi Y, et al. Erythropoietin in traumatic brain injury (EPO-TBI): a double-blind randomised controlled trial. Lancet. 2015; 386(10012): 2499-506[DOI][PubMed]
  • 10. Presneill J, Little L, Nichol A, French C, Cooper DJ, Haddad S, et al. Statistical analysis plan for the Erythropoietin in Traumatic Brain Injury trial: a randomised controlled trial of erythropoietin versus placebo in moderate and severe traumatic brain injury. Trials. 2014; 15: 501[DOI][PubMed]
  • 11. Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions. 2011;
  • 12. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003; 327(7414): 557-60[DOI][PubMed]
  • 13. Mammis A, McIntosh TK, Maniker AH. Erythropoietin as a neuroprotective agent in traumatic brain injury Review. Surg Neurol. 2009; 71(5): 527-31[DOI][PubMed]
  • 14. Talving P, Lustenberger T, Kobayashi L, Inaba K, Barmparas G, Schnuriger B, et al. Erythropoiesis stimulating agent administration improves survival after severe traumatic brain injury: a matched case control study. Ann Surg. 2010; 251(1): 1-4[DOI][PubMed]
  • 15. Aloizos S, Evodia E, Gourgiotis S, Isaia EC, Seretis C, Baltopoulos GJ. Neuroprotective Effects of Erythropoietin in Patients with Severe Closed Brain Injury. Turk Neurosurg. 2015; 25(4): 552-8[DOI][PubMed]
  • 16. Leucht S, Helfer B, Gartlehner G, Davis JM. How effective are common medications: a perspective based on meta-analyses of major drugs. BMC Med. 2015; 13: 253[DOI][PubMed]
  • 17. Zafonte RD, Bagiella E, Ansel BM, Novack TA, Friedewald WT, Hesdorffer DC, et al. Effect of citicoline on functional and cognitive status among patients with traumatic brain injury: Citicoline Brain Injury Treatment Trial (COBRIT). JAMA. 2012; 308(19): 1993-2000[DOI][PubMed]
  • 18. Skolnick BE, Maas AI, Narayan RK, van der Hoop RG, MacAllister T, Ward JD, et al. A clinical trial of progesterone for severe traumatic brain injury. N Engl J Med. 2014; 371(26): 2467-76[DOI][PubMed]
  • 19. Wright DW, Yeatts SD, Silbergleit R, Palesch YY, Hertzberg VS, Frankel M, et al. Very early administration of progesterone for acute traumatic brain injury. N Engl J Med. 2014; 371(26): 2457-66[DOI][PubMed]
  • 20. Menon DK. Unique challenges in clinical trials in traumatic brain injury. Crit Care Med. 2009; 37(1 Suppl): 129-35[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments