Trauma Monthly

Published by: Kowsar

Overview of Agents Used for Emergency Hemostasis

Hadi Khoshmohabat 1 , Shahram Paydar 2 , 3 , Hossein Mohammad Kazemi 1 and Behnam Dalfardi 1 , 2 , *
Authors Information
1 Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
2 Trauma Research Center, Shahid Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, IR Iran
3 Department of General Surgery, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran
Article information
  • Trauma Monthly: February 1, 2016, 21 (1); e26023
  • Published Online: February 6, 2016
  • Article Type: Review Article
  • Received: December 11, 2014
  • Revised: April 19, 2015
  • Accepted: May 25, 2015
  • DOI: 10.5812/traumamon.26023

To Cite: Khoshmohabat H, Paydar S, Kazemi H M, Dalfardi B. Overview of Agents Used for Emergency Hemostasis, Trauma Mon. 2016 ; 21(1):e26023. doi: 10.5812/traumamon.26023.

Abstract
Copyright © 2016, Trauma Monthly. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Evidence Acquisition
3. Results
4. Conclusions
Footnote
References
  • 1. Morrison CA. The prehospital treatment of the bleeding patient--dare to dream. J Surg Res. 2013; 180(2): 246-7[DOI][PubMed]
  • 2. Sambasivan CN, Cho SD, Zink KA, Differding JA, Schreiber MA. A highly porous silica and chitosan-based hemostatic dressing is superior in controlling hemorrhage in a severe groin injury model in swine. Am J Surg. 2009; 197(5): 576-80[DOI][PubMed]
  • 3. Lier H, Krep H, Schroeder S, Stuber F. Preconditions of hemostasis in trauma: a review. The influence of acidosis, hypocalcemia, anemia, and hypothermia on functional hemostasis in trauma. J Trauma. 2008; 65(4): 951-60[DOI][PubMed]
  • 4. Taylor LM, Mueller-Velten G, Koslow A, Hunter G, Naslund T, Kline R. Prospective randomized multicenter trial of fibrin sealant versus thrombin-soaked gelatin sponge for suture- or needle-hole bleeding from polytetrafluoroethylene femoral artery grafts. J Vasc Surg. 2003; 38(4): 766-71[PubMed]
  • 5. Dai C, Liu C, Wei J, Hong H, Zhao Q. Molecular imprinted macroporous chitosan coated mesoporous silica xerogels for hemorrhage control. Biomaterials. 2010; 31(30): 7620-30[DOI][PubMed]
  • 6. Rothwell SW, Fudge JM, Chen WK, Reid TJ, Krishnamurti C. Addition of a propyl gallate-based procoagulant to a fibrin bandage improves hemostatic performance in a swine arterial bleeding model. Thromb Res. 2002; 108(5-6): 335-40[PubMed]
  • 7. Gruen RL, Brohi K, Schreiber M, Balogh ZJ, Pitt V, Narayan M, et al. Haemorrhage control in severely injured patients. Lancet. 2012; 380(9847): 1099-108[DOI][PubMed]
  • 8. Bilgili H, Kosar A, Kurt M, Onal IK, Goker H, Captug O, et al. Hemostatic efficacy of Ankaferd Blood Stopper in a swine bleeding model. Med Princ Pract. 2009; 18(3): 165-9[DOI][PubMed]
  • 9. Mannucci PM. Hemostatic drugs. N Engl J Med. 1998; 339(4): 245-53[DOI][PubMed]
  • 10. Rossaint R, Cerny V, Coats TJ, Duranteau J, Fernandez-Mondejar E, Gordini G, et al. Key issues in advanced bleeding care in trauma. Shock. 2006; 26(4): 322-31[DOI][PubMed]
  • 11. Kelly JF, Ritenour AE, McLaughlin DF, Bagg KA, Apodaca AN, Mallak CT, et al. Injury severity and causes of death from Operation Iraqi Freedom and Operation Enduring Freedom: 2003-2004 versus 2006. J Trauma. 2008; 64(2 Suppl)-6[DOI][PubMed]
  • 12. Granville-Chapman J, Jacobs N, Midwinter MJ. Pre-hospital haemostatic dressings: a systematic review. Injury. 2011; 42(5): 447-59[DOI][PubMed]
  • 13. Vournakis JN, Demcheva M, Whitson AB, Finkielsztein S, Connolly RJ. The RDH bandage: hemostasis and survival in a lethal aortotomy hemorrhage model. J Surg Res. 2003; 113(1): 1-5[PubMed]
  • 14. Mabry RL, Holcomb JB, Baker AM, Cloonan CC, Uhorchak JM, Perkins DE, et al. United States Army Rangers in Somalia: an analysis of combat casualties on an urban battlefield. J Trauma. 2000; 49(3): 515-28[PubMed]
  • 15. Navein J, Coupland R, Dunn R. The tourniquet controversy. J Trauma. 2003; 54(5 Suppl)-20[DOI][PubMed]
  • 16. Carraway JW, Kent D, Young K, Cole A, Friedman R, Ward KR. Comparison of a new mineral based hemostatic agent to a commercially available granular zeolite agent for hemostasis in a swine model of lethal extremity arterial hemorrhage. Resuscitation. 2008; 78(2): 230-5[DOI][PubMed]
  • 17. Ward KR, Tiba MH, Holbert WH, Blocher CR, Draucker GT, Proffitt EK, et al. Comparison of a new hemostatic agent to current combat hemostatic agents in a Swine model of lethal extremity arterial hemorrhage. J Trauma. 2007; 63(2): 276-83[DOI][PubMed]
  • 18. Yucel N, Lefering R, Maegele M, Vorweg M, Tjardes T, Ruchholtz S, et al. Trauma Associated Severe Hemorrhage (TASH)-Score: probability of mass transfusion as surrogate for life threatening hemorrhage after multiple trauma. J Trauma. 2006; 60(6): 1228-36[DOI][PubMed]
  • 19. Brohi K, Singh J, Heron M, Coats T. Acute traumatic coagulopathy. J Trauma. 2003; 54(6): 1127-30[DOI][PubMed]
  • 20. Davenport R, Manson J, De'Ath H, Platton S, Coates A, Allard S, et al. Functional definition and characterization of acute traumatic coagulopathy. Crit Care Med. 2011; 39(12): 2652-8[DOI][PubMed]
  • 21. Pusateri AE, McCarthy SJ, Gregory KW, Harris RA, Cardenas L, McManus AT, et al. Effect of a chitosan-based hemostatic dressing on blood loss and survival in a model of severe venous hemorrhage and hepatic injury in swine. J Trauma. 2003; 54(1): 177-82[DOI][PubMed]
  • 22. Smith AH, Laird C, Porter K, Bloch M. Haemostatic dressings in prehospital care. Emerg Med J. 2013; 30(10): 784-9[DOI][PubMed]
  • 23. Clay JG, Zierold D, Grayson K, Battistella FD. Dextran polymer hemostatic dressing improves survival in liver injury model. J Surg Res. 2009; 155(1): 89-93[DOI][PubMed]
  • 24. Kilbourne M, Keledjian K, Hess JR, Scalea T, Bochicchio GV. Hemostatic efficacy of modified amylopectin powder in a lethal porcine model of extremity arterial injury. Ann Emerg Med. 2009; 53(6): 804-10[DOI][PubMed]
  • 25. Pusateri AE, Holcomb JB, Kheirabadi BS, Alam HB, Wade CE, Ryan KL. Making sense of the preclinical literature on advanced hemostatic products. J Trauma. 2006; 60(3): 674-82[DOI][PubMed]
  • 26. Robinson K. Controlling bleeding in the field: hemostatic powders and dressings debut in the prehospital setting. J Emerg Nurs. 2004; 30(2): 160-1[DOI][PubMed]
  • 27. Lawton G, Granville-Chapman J, Parker PJ. Novel haemostatic dressings. J R Army Med Corps. 2009; 155(4): 309-14[PubMed]
  • 28. Bennett BL, Littlejohn L. Review of new topical hemostatic dressings for combat casualty care. Mil Med. 2014; 179(5): 497-514[DOI][PubMed]
  • 29. Kratz A, Danon A. Controlling bleeding from superficial wounds by the use of topical alpha adrenoreceptor agonists spray. A randomized, masked, controlled study. Injury. 2004; 35(11): 1096-101[DOI][PubMed]
  • 30. Devlin JJ, Kircher S, Kozen BG, Littlejohn LF, Johnson AS. Comparison of ChitoFlex(R), CELOX, and QuikClot(R) in control of hemorrhage. J Emerg Med. 2011; 41(3): 237-45[DOI][PubMed]
  • 31. Clay JG, Grayson JK, Zierold D. Comparative testing of new hemostatic agents in a swine model of extremity arterial and venous hemorrhage. Mil Med. 2010; 175(4): 280-4[PubMed]
  • 32. Valeri CR, Vournakis JN. mRDH bandage for surgery and trauma: data summary and comparative review. J Trauma. 2011; 71(2 Suppl 1)-6[DOI][PubMed]
  • 33. Rhee P, Brown C, Martin M, Salim A, Plurad D, Green D, et al. QuikClot use in trauma for hemorrhage control: case series of 103 documented uses. J Trauma. 2008; 64(4): 1093-9[DOI][PubMed]
  • 34. Arnaud F, Tomori T, Carr W, McKeague A, Teranishi K, Prusaczyk K, et al. Exothermic reaction in zeolite hemostatic dressings: QuikClot ACS and ACS+. Ann Biomed Eng. 2008; 36(10): 1708-13[DOI][PubMed]
  • 35. Velmahos GC, Tabbara M, Spaniolas K, Duggan M, Alam HB, Serra M, et al. Self-expanding hemostatic polymer for control of exsanguinating extremity bleeding. J Trauma. 2009; 66(4): 984-8[DOI][PubMed]
  • 36. Sambasivan CN, Schreiber MA. Emerging therapies in traumatic hemorrhage control. Curr Opin Crit Care. 2009; 15(6): 560-8[DOI][PubMed]
  • 37. Millner RW, Lockhart AS, Bird H, Alexiou C. A new hemostatic agent: initial life-saving experience with Celox (chitosan) in cardiothoracic surgery. Ann Thorac Surg. 2009; 87(2)-4[DOI][PubMed]
  • 38. Pozza M, Millner RW. Celox (chitosan) for haemostasis in massive traumatic bleeding: experience in Afghanistan. Eur J Emerg Med. 2011; 18(1): 31-3[DOI][PubMed]
  • 39. King DR, Schreiber MA. The mRDH bandage provides effective hemostasis in trauma and surgical hemorrhage. J Trauma. 2011; 71(2 Suppl 1)-70[DOI][PubMed]
  • 40. Arnaud F, Teranishi K, Okada T, Parreno-Sacdalan D, Hupalo D, McNamee G, et al. Comparison of Combat Gauze and TraumaStat in two severe groin injury models. J Surg Res. 2011; 169(1): 92-8[DOI][PubMed]
  • 41. Malmquist JP, Clemens SC, Oien HJ, Wilson SL. Hemostasis of oral surgery wounds with the HemCon Dental Dressing. J Oral Maxillofac Surg. 2008; 66(6): 1177-83[DOI][PubMed]
  • 42. Gerlach T, Grayson JK, Pichakron KO, Sena MJ, DeMartini SD, Clark BZ, et al. Preliminary study of the effects of smectite granules (WoundStat) on vascular repair and wound healing in a swine survival model. J Trauma. 2010; 69(5): 1203-9[DOI][PubMed]
  • 43. Kheirabadi BS, Mace JE, Terrazas IB, Fedyk CG, Estep JS, Dubick MA, et al. Safety evaluation of new hemostatic agents, smectite granules, and kaolin-coated gauze in a vascular injury wound model in swine. J Trauma. 2010; 68(2): 269-78[DOI][PubMed]
  • 44. Wright JK, Kalns J, Wolf EA, Traweek F, Schwarz S, Loeffler CK, et al. Thermal injury resulting from application of a granular mineral hemostatic agent. J Trauma. 2004; 57(2): 224-30[PubMed]
  • 45. Ong SY, Wu J, Moochhala SM, Tan MH, Lu J. Development of a chitosan-based wound dressing with improved hemostatic and antimicrobial properties. Biomaterials. 2008; 29(32): 4323-32[DOI][PubMed]
  • 46. Kheirabadi BS, Scherer MR, Estep JS, Dubick MA, Holcomb JB. Determination of efficacy of new hemostatic dressings in a model of extremity arterial hemorrhage in swine. J Trauma. 2009; 67(3): 450-9[DOI][PubMed]
  • 47. Waibel KH, Haney B, Moore M, Whisman B, Gomez R. Safety of chitosan bandages in shellfish allergic patients. Mil Med. 2011; 176(10): 1153-6[PubMed]
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