Trauma Monthly

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Use of Ferric Sulfate to Control Hepatic Bleeding

Saeed Nouri 1 and Mohammad Reza Sharif 2 , *
Authors Information
1 Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
2 Trauma Research Center, Kashan University of Medical Sciences, Kashan, IR Iran
Article information
  • Trauma Monthly: February 28, 2015, 20 (1); e25257
  • Published Online: January 1, 2015
  • Article Type: Research Article
  • Received: November 10, 2014
  • Revised: December 1, 2014
  • Accepted: December 1, 2014
  • DOI: 10.5812/traumamon.25257

To Cite: Nouri S, Sharif M R. Use of Ferric Sulfate to Control Hepatic Bleeding, Trauma Mon. 2015 ; 20(1):e25257. doi: 10.5812/traumamon.25257.

Copyright © 2015, Trauma Monthly. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Holt DR, Thiel DV, Edelstein S, Brems JJ. Hepatic resections. Arch Surg. 2000; 135(11): 1353-8[PubMed]
  • 2. Jarnagin WR, Gonen M, Fong Y, DeMatteo RP, Ben-Porat L, Little S, et al. Improvement in perioperative outcome after hepatic resection: analysis of 1,803 consecutive cases over the past decade. Ann Surg. 2002; 236(4): 397-406[DOI][PubMed]
  • 3. Makuuchi M, Sano K. The surgical approach to HCC: our progress and results in Japan. Liver Transpl. 2004; 10(2 Suppl 1)-52[DOI][PubMed]
  • 4. Clark WR, Leather RP. Hemostasis during liver resections. Surgery. 1970; 67(3): 556-7
  • 5. Helewski K, Kowalczyk-Ziomek G, Czecior E, Wyrobiec G, Harabin-Slowinska M, Juszko-Piekut M, et al. Protective effect of intermittent clamping of the portal triad in the rat liver on liver ischemia-reperfusion injury. Hepat Mon. 2011; 11(6): 445-51[PubMed]
  • 6. Bechstein WO, Neuhaus P. [Bleeding problems in liver surgery and liver transplantation]. Chirurg. 2000; 71(4): 363-8[PubMed]
  • 7. Cogbill TH, Moore EE, Jurkovich GJ, Feliciano DV, Morris JA, Mucha P. Severe hepatic trauma: a multi-center experience with 1,335 liver injuries. J Trauma. 1988; 28(10): 1433-8[PubMed]
  • 8. Beal SL. Fatal hepatic hemorrhage: an unresolved problem in the management of complex liver injuries. J Trauma. 1990; 30(2): 163-9[PubMed]
  • 9. David Richardson J, Franklin GA, Lukan JK, Carrillo EH, Spain DA, Miller FB, et al. Evolution in the management of hepatic trauma: a 25-year perspective. Ann Surg. 2000; 232(3): 324-30[PubMed]
  • 10. Fischer DE. Tissue management: a new solution to an old problem. Gen Dent. 1987; 35(3): 178-82[PubMed]
  • 11. Smith NL, Seale NS, Nunn ME. Ferric sulfate pulpotomy in primary molars: a retrospective study. Pediatr Dent. 2000; 22(3): 192-9[PubMed]
  • 12. Nouri S, Sharif MR. Efficacy and safety of ferric chloride in controlling hepatic bleeding; an animal model study. Hepat Mon. 2014; 14(6)[DOI][PubMed]
  • 13. Nouri S, Amirbeigy M, Hosseinpour M, Abdorrahim K, Sharif MR, Amirbeigy M:. Evaluation of the Hemostatic Effect of Ferric Sulfate in Controlling Liver Bleeding in Mouse at Kashan University of Medical Sciences, 2012. Iranian J Surg. 2013; 21(21-29)
  • 14. Carrillo EH, Richardson JD. The current management of hepatic trauma. Adv Surg. 2001; 35: 39-59[PubMed]
  • 15. Boonstra EA, Molenaar IQ, Porte RJ, de Boer MT. Topical haemostatic agents in liver surgery: do we need them? HPB (Oxford). 2009; 11(4): 306-10[DOI][PubMed]
  • 16. Figueras J, Llado L, Miro M, Ramos E, Torras J, Fabregat J, et al. Application of fibrin glue sealant after hepatectomy does not seem justified: results of a randomized study in 300 patients. Ann Surg. 2007; 245(4): 536-42[DOI][PubMed]
  • 17. Berrevoet F, de Hemptinne B. Use of topical hemostatic agents during liver resection. Dig Surg. 2007; 24(4): 288-93[DOI][PubMed]
  • 18. Heaton N. Advances and methods in liver surgery: haemostasis. Eur J Gastroenterol Hepatol. 2005; 17 Suppl 1-12[PubMed]
  • 19. Nouri S, Sharif MR, Tabatabaei F, Farokhi S. Investigating the effect of zinc chloride to control external bleeding in rats. Nurs Midwifery Stud. 2014; 3(3)
  • 20. Lemon RR, Steele PJ, Jeansonne BG. Ferric sulfate hemostasis: effect on osseous wound healing. Left in situ for maximum exposure. J Endod. 1993; 19(4): 170-3[PubMed]
  • 21. Li W, McIntyre TM, Silverstein RL. Ferric chloride-induced murine carotid arterial injury: A model of redox pathology. Redox Biol. 2013; 1(1): 50-5[DOI][PubMed]
  • 22. Larson PO. Topical hemostatic agents for dermatologic surgery. J Dermatol Surg Oncol. 1988; 14(6): 623-32[PubMed]
  • 23. Material Safety Data Sheet – Ferric Sulfate 50% (10% Fe3+) . 2014;
  • 24. Nouri S, Sharif MR. Hemostatic effect of aluminum chloride in liver bleeding: an animal model study. Tehran Univ Med J. 2014; 72(7): 435-42
  • 25. Cinar C, Odabas ME, Akca G, Isik B. Antibacterial effect of a new haemostatic agent on oral microorganisms. J Clin Exp Dent. 2012; 4(3)-5[DOI][PubMed]
  • 26. Kim S, Rethnam S. Hemostasis in endodontic microsurgery. Dent Clin North Am. 1997; 41(3): 499-511[PubMed]
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