Trauma Monthly

Published by: Kowsar

Topical Nicotinamide Improves Tissue Regeneration in Excisional Full-Thickness Skin Wounds: A Stereological and Pathological Study

Soheil Ashkani Esfahani 1 , Mahsima Khoshneviszadeh 2 , Mohammad Reza Namazi 3 , Ali Noorafshan 4 , * , Bita Geramizadeh 5 , Elham Nadimi 4 and Seyedeh Tahereh Razavipour 6
Authors Information
1 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, IR Iran
2 Medicinal and Natural Product Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
3 Skin Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
4 Histomorphometry and Stereology Research Centre, Shiraz University of Medical Sciences, Shiraz, IR Iran
5 Organ Transplant Research Center, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, IR Iran
6 Payam-e-Nour University, Shiraz, IR Iran
Article information
  • Trauma Monthly: November 1, 2015, 20 (4); e18193
  • Published Online: November 23, 2015
  • Article Type: Research Article
  • Received: February 12, 2014
  • Revised: June 20, 2014
  • Accepted: June 29, 2014
  • DOI: 10.5812/traumamon.18193

To Cite: Ashkani Esfahani S, Khoshneviszadeh M, Namazi M R, Noorafshan A, Geramizadeh B, et al. Topical Nicotinamide Improves Tissue Regeneration in Excisional Full-Thickness Skin Wounds: A Stereological and Pathological Study, Trauma Mon. 2015 ; 20(4):e18193. doi: 10.5812/traumamon.18193.

Abstract
Copyright © 2015, Trauma Monthly. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Clark R. The molecular and cellular biology of wound repair. 1996;
  • 2. Lappas M, Permezel M. The anti-inflammatory and antioxidative effects of nicotinamide, a vitamin B(3) derivative, are elicited by FoxO3 in human gestational tissues: implications for preterm birth. J Nutr Biochem. 2011; 22(12): 1195-201[DOI][PubMed]
  • 3. Virag L, Szabo C. The therapeutic potential of poly (ADP-ribose) polymerase inhibitors. Pharmacol Rev. 2002; 54(3): 375-429[DOI]
  • 4. Myczkowski T. [Healing of the donor area after transplantation of splitted grafts]. Med Klin. 1975; 70(19): 861-6[PubMed]
  • 5. Collins TM, Caimi R, Lynch PR, Sheffield J, Mitra A, Stueber K, et al. The effects of nicotinamide and hyperbaric oxygen on skin flap survival. Scand J Plast Reconstr Surg Hand Surg. 1991; 25(1): 5-7[PubMed]
  • 6. Iraji F, Banan L. The efficacy of nicotinamide gel 4% as an adjuvant therapy in the treatment of cutaneous erosions of pemphigus vulgaris. Dermatol Ther. 2010; 23(3): 308-11[DOI][PubMed]
  • 7. Ashkani-Esfahani S, Imanieh MH, Meshksar A, Khoshneviszadeh M, Noorafshan A, Geramizadeh B, et al. Enhancement of fibroblast proliferation, vascularization and collagen synthesis in the healing process of third-degree burn wounds by topical arnebia euchroma, a herbal medicine. Galen Med J. 2013; 1(2): 53-9
  • 8. Ashkani-Esfahani S, Imanieh MH, Khoshneviszadeh M, Meshksar A, Noorafshan A, Geramizadeh B, et al. The healing effect of arnebia euchroma in second degree burn wounds in rat as an animal model. Iran Red Cres Med J. 2012; 14(2): 70-4
  • 9. Gundersen HJ, Bendtsen TF, Korbo L, Marcussen N, Moller A, Nielsen K, et al. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS. 1988; 96(5): 379-94[PubMed]
  • 10. Ashkani-Esfahani S, Emami Y, Esmaeilzadeh E, Bagheri F, Namazi MR, Keshtkar M, et al. Silymarin enhanced fibroblast proliferation and tissue regeneration in full thickness skin wounds in rat models; a stereological study. J Saudi Soc Dermatol Dermatol Surg. 2013; 17(1): 7-12[DOI]
  • 11. Maiese K, Chong ZZ, Hou J, Shang YC. The vitamin nicotinamide: translating nutrition into clinical care. Molecules. 2009; 14(9): 3446-85[DOI][PubMed]
  • 12. Hakozaki T, Minwalla L, Zhuang J, Chhoa M, Matsubara A, Miyamoto K, et al. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. Br J Dermatol. 2002; 147(1): 20-31[PubMed]
  • 13. Knip M, Douek IF, Moore WP, Gillmor HA, McLean AE, Bingley PJ, et al. Safety of high-dose nicotinamide: a review. Diabetologia. 2000; 43(11): 1337-45[DOI][PubMed]
  • 14. Damian DL, Patterson CR, Stapelberg M, Park J, Barnetson RS, Halliday GM. UV radiation-induced immunosuppression is greater in men and prevented by topical nicotinamide. J Invest Dermatol. 2008; 128(2): 447-54[DOI][PubMed]
  • 15. Biedron R, Ciszek M, Tokarczyk M, Bobek M, Kurnyta M, Slominska EM, et al. 1-Methylnicotinamide and nicotinamide: two related anti-inflammatory agents that differentially affect the functions of activated macrophages. Arch Immunol Ther Exp (Warsz). 2008; 56(2): 127-34[DOI][PubMed]
  • 16. Tanno O, Ota Y, Kitamura N, Katsube T, Inoue S. Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. Br J Dermatol. 2000; 143(3): 524-31[PubMed]
  • 17. Smith YR, Klitzman B, Ellis MN, Kull FJ. The effect of nicotinamide on microvascular density and thermal injury in rats. J Surg Res. 1989; 47(5): 465-9[PubMed]
  • 18. Morganti P, Berardesca E, Guarneri B, Guarneri F, Fabrizi G, Palombo P, et al. Topical clindamycin 1% vs. linoleic acid-rich phosphatidylcholine and nicotinamide 4% in the treatment of acne: a multicentre-randomized trial. Int J Cosmet Sci. 2011; 33(5): 467-76[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments