Trauma Monthly

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Analgesic Effect of Clonidine Added to Bupivacaine in Spinal Anesthesia for Cruciate Ligament Repair

Marzieh Lak 1 , Asghar Yousefi 1 , Hamidreza Karimi-Sari 2 and Masoud Saghafinia 1 , *
Authors Information
1 Trauma Research Center, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
2 Students’ Research Committee (SRC), Baqiyatallah University of Medical Sciences, Tehran, IR Iran
Article information
  • Trauma Monthly: May 31, 2015, 20 (2); e17879
  • Published Online: May 20, 2015
  • Article Type: Research Article
  • Received: January 28, 2014
  • Revised: May 17, 2014
  • Accepted: July 27, 2014
  • DOI: 10.5812/traumamon.17879

To Cite: Lak M, Yousefi A, Karimi-Sari H, Saghafinia M. Analgesic Effect of Clonidine Added to Bupivacaine in Spinal Anesthesia for Cruciate Ligament Repair, Trauma Mon. 2015 ; 20(2):e17879. doi: 10.5812/traumamon.17879.

Copyright © 2015, Trauma Monthly. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Kohli S, Kaur M, Sahoo S, Vajifdar H, Kohli P. Brachial plexus block: Comparison of two different doses of clonidine added to bupivacaine. J Anaesthesiol Clin Pharmacol. 2013; 29(4): 491-5[DOI][PubMed]
  • 2. Reuben SS, Connelly NR. Postoperative analgesia for outpatient arthroscopic knee surgery with intraarticular clonidine. Anesth Analg. 1999; 88(4): 729-33[PubMed]
  • 3. Bales CP, Guettler JH, Moorman C3. Anterior cruciate ligament injuries in children with open physes: evolving strategies of treatment. Am J Sports Med. 2004; 32(8): 1978-85[PubMed]
  • 4. Saravana Babu M, Verma AK, Agarwal A, Tyagi CM, Upadhyay M, Tripathi S. A comparative study in the post-operative spine surgeries: Epidural ropivacaine with dexmedetomidine and ropivacaine with clonidine for post-operative analgesia. Indian J Anaesth. 2013; 57(4): 371-6[DOI][PubMed]
  • 5. Iskandar H, Benard A, Ruel-Raymond J, Cochard G, Manaud B. The analgesic effect of interscalene block using clonidine as an analgesic for shoulder arthroscopy. Anesth Analg. 2003; 96(1): 260-2[PubMed]
  • 6. Boselli E, Daniela-Ionescu M, Begou G, Bouvet L, Dabouz R, Magnin C, et al. Prospective observational study of the non-invasive assessment of immediate postoperative pain using the analgesia/nociception index (ANI). Br J Anaesth. 2013; 111(3): 453-9[DOI][PubMed]
  • 7. Dobrydnjov I, Axelsson K, Thorn SE, Matthiesen P, Klockhoff H, Holmstrom B, et al. Clonidine combined with small-dose bupivacaine during spinal anesthesia for inguinal herniorrhaphy: a randomized double-blinded study. Anesth Analg. 2003; 96(5): 1496-503[PubMed]
  • 8. van Tuijl I, van Klei WA, van der Werff DB, Kalkman CJ. The effect of addition of intrathecal clonidine to hyperbaric bupivacaine on postoperative pain and morphine requirements after Caesarean section: a randomized controlled trial. Br J Anaesth. 2006; 97(3): 365-70[DOI][PubMed]
  • 9. Grandge R, Wig J, Yaddanapudi L. Evaluation of bupivacaine-clonidine combination for unilateral spinal anaesthesia in lower limb orthopedic surgery. J Anaesthesiol Clin Pharmacol. 2008; 24(2): 155
  • 10. Lavand'homme PM, Roelants F, Waterloos H, Collet V, De Kock MF. An evaluation of the postoperative antihyperalgesic and analgesic effects of intrathecal clonidine administered during elective cesarean delivery. Anesth Analg. 2008; 107(3): 948-55[DOI][PubMed]
  • 11. Thakur A, Bhardwaj M, Kaur K, Dureja J, Hooda S, Taxak S. Intrathecal clonidine as an adjuvant to hyperbaric bupivacaine in patients undergoing inguinal herniorrhaphy: A randomized double-blinded study. J Anaesthesiol Clin Pharmacol. 2013; 29(1): 66-70[DOI][PubMed]
  • 12. Kaabachi O, Zarghouni A, Ouezini R, Abdelaziz AB, Chattaoui O, Kokki H. Clonidine 1 microg/kg is a safe and effective adjuvant to plain bupivacaine in spinal anesthesia in adolescents. Anesth Analg. 2007; 105(2): 516-9[DOI][PubMed]
  • 13. Bhure A, Kalita N, Ingley P, Gadkari C. Comparative study of intrathecal hyperbaric Bupivacaine with Clonidine, Fentanyl and Midazolam for quality of anaesthesia and duration of post operative pain relief in patients undergoing elective caesarean section. People's J Sci Res. 2012; 5(1): 19-23
  • 14. Imani F, Salmanian R, Feiz H. Comparison of co-administration of clonidine and pethidine with bupivacaine during spinal anesthesia. Zahedan J Res in Med Sci. 2011; 13(2): 31-7
  • 15. Shah B, Shidhaye R, Divekar D, Panditrao M, Panditrao M, Suryawanshi C. A randomized, double blind, controlled study on the effects of addition of clonidine to bupivacaine used for patients undergoing spinal anaesthesia. Sri Lankan Journal of Anaesthesiology. 2011; 19(1)[DOI]
  • 16. Joshi SA, Khadke VV, Subhedar RD, Patil AW, Motghare VM. Comparative evaluation of intrathecal midazolam and low dose clonidine: efficacy, safety and duration of analgesia. A randomized, double blind, prospective clinical trial. Indian J Pharmacol. 2012; 44(3): 357-61[DOI][PubMed]
  • 17. Gecaj-Gashi A, Terziqi H, Pervorfi T, Kryeziu A. Intrathecal clonidine added to small-dose bupivacaine prolongs postoperative analgesia in patients undergoing transurethral surgery. Can Urol Assoc J. 2012; 6(1): 25-9[DOI][PubMed]
  • 18. Jamliya RH, Vansola R, Shah B, Chauhan DL. Effect of Clonidine Addition To Hyperbaric 0.5% Bupivacaine For Spinal Anaesthesia In Lower Limb Surgery :A Comparative Study. National J Integrated Res in Med. 2012; 3(1)
  • 19. Sites BD, Beach M, Biggs R, Rohan C, Wiley C, Rassias A, et al. Intrathecal Clonidine Added to a Bupivacaine-Morphine Spinal Anesthetic Improves Postoperative Analgesia for Total Knee Arthroplasty. Anesthesia & Analgesia. 2003; : 1083-8[DOI]
  • 20. Lak M, Araghizadeh H, Shayeghi S, Khatibi B. Addition of clonidine in caudal anesthesia in children increases duration of post-operative analgesia. Trauma Mon. 2012; 16(4): 170-4[DOI][PubMed]
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