Trauma Monthly

Published by: Kowsar

Matricaria Chamomilla Extract Improves Diabetic Wound Healing in Rat Models

Parisa Nematollahi 1 , Nasrin Mohammadi Aref 2 , Farzaneh Zahmatkesh Meimandi 1 , Seyede Laya Rozei 2 , Hamidreza Zareé 1 , Seyyed Mohammad Javad Mirlohi 2 , Shima Rafiee 1 , Maryam Mohsenikia 3 , Ali Soleymani 4 , Soheil Ashkani-Esfahani 1 , * , Alireza Ebrahimi 1 and Ali Noorafshan 5
Authors Information
1 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
2 Student Research Committee, Tehran Medical Sciences Branch, Islamic Azad University, Iran
3 Young Researchers and Elite Club, Tehran Medical Branch, Islamic Azad University, Tehran, Iran
4 Dezful University of Medical Sciences, Dezful, Iran
5 Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Article information
  • Trauma Monthly: 24 (3); e14318
  • Published Online: April 9, 2019
  • Article Type: Research Article
  • Received: May 30, 2017
  • Revised: September 26, 2018
  • Accepted: October 14, 2018
  • DOI: 10.5812/traumamon.14318

To Cite: Nematollahi P, Mohammadi Aref N, Zahmatkesh Meimandi F , Rozei S L, Zareé H , et al. Matricaria Chamomilla Extract Improves Diabetic Wound Healing in Rat Models, Trauma Mon. Online ahead of Print ; 24(3):e14318. doi: 10.5812/traumamon.14318.

Copyright © 2019, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Farzaei MH, Abbasabadi Z, Shams-Ardekani MR, Abdollahi M, Rahimi R. A comprehensive review of plants and their active constituents with wound healing activity in traditional Iranian medicine. Wounds. 2014;26(7):197-206.
  • 2. Guo S, Dipietro LA. Factors affecting wound healing. J Dent Res. 2010;89(3):219-29. doi: 10.1177/0022034509359125. [PubMed: 20139336]. [PubMed Central: PMC2903966].
  • 3. Galkowska H, Wojewodzka U, Olszewski WL. Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcers. Wound Repair Regen. 2006;14(5):558-65. doi: 10.1111/j.1743-6109.2006.00155.x. [PubMed: 17014667].
  • 4. Falanga V. Wound healing and its impairment in the diabetic foot. Lancet. 2005;366(9498):1736-43. doi: 10.1016/S0140-6736(05)67700-8. [PubMed: 16291068].
  • 5. Saaristo A, Tammela T, Farkkila A, Karkkainen M, Suominen E, Yla-Herttuala S, et al. Vascular endothelial growth factor-C accelerates diabetic wound healing. Am J Pathol. 2006;169(3):1080-7. doi: 10.2353/ajpath.2006.051251. [PubMed: 16936280]. [PubMed Central: PMC1698814].
  • 6. Kalay Z, Cevher SC. Oxidant and antioxidant events during epidermal growth factor therapy to cutaneous wound healing in rats. Int Wound J. 2012;9(4):362-71. doi: 10.1111/j.1742-481X.2011.00895.x. [PubMed: 22129466].
  • 7. Saddiqe Z, Naeem I, Maimoona A. A review of the antibacterial activity of Hypericum perforatum L. J Ethnopharmacol. 2010;131(3):511-21. doi: 10.1016/j.jep.2010.07.034. [PubMed: 20659547].
  • 8. Bagheri M, Jahromi BM, Mirkhani H, Solhjou Z, Noorafshan A, Zamani A, et al. Azelnidipine, a new calcium channel blocker, promotes skin wound healing in diabetic rats. J Surg Res. 2011;169(1):e101-7. doi: 10.1016/j.jss.2011.02.039.
  • 9. Rhoads DD, Cox SB, Rees EJ, Sun Y, Wolcott RD. Clinical identification of bacteria in human chronic wound infections: Culturing vs. 16S ribosomal DNA sequencing. BMC Infect Dis. 2012;12:321. doi: 10.1186/1471-2334-12-321. [PubMed: 23176603]. [PubMed Central: PMC3542000].
  • 10. Kumar B, Vijayakumar M, Govindarajan R, Pushpangadan P. Ethnopharmacological approaches to wound healing--exploring medicinal plants of India. J Ethnopharmacol. 2007;114(2):103-13. doi: 10.1016/j.jep.2007.08.010. [PubMed: 17884316].
  • 11. Avallone R, Zanoli P, Puia G, Kleinschnitz M, Schreier P, Baraldi M. Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. Biochem Pharmacol. 2000;59(11):1387-94. [PubMed: 10751547].
  • 12. Rezaie A, Mohajeri D, Zarkhah A, Nazeri M. Comparative assessment of Matricaria chamomilla and zinc oxide on healing of experimental skin wounds on rats. Ann Biol Res. 2012;3(1):550-60.
  • 13. Jarrahi M. An experimental study of the effects of Matricaria chamomilla extract on cutaneous burn wound healing in albino rats. Nat Prod Res. 2008;22(5):422-7. doi: 10.1080/14786410701591713. [PubMed: 18404562].
  • 14. Szoke E, Maday E, Tyihak E, Kuzovkina IN, Lemberkovics E. New terpenoids in cultivated and wild chamomile (in vivo and in vitro). J Chromatogr B Analyt Technol Biomed Life Sci. 2004;800(1-2):231-8. [PubMed: 14698259].
  • 15. Lyseng-Williamson KA, Perry CM. Micronised purified flavonoid fraction: A review of its use in chronic venous insufficiency, venous ulcers and haemorrhoids. Drugs. 2003;63(1):71-100. doi: 10.2165/00003495-200363010-00005. [PubMed: 12487623].
  • 16. Gardiner P. Complementary, holistic, and integrative medicine: Chamomile. Pediatr Rev. 2007;28(4):e16-8. [PubMed: 17400821].
  • 17. Way TD, Kao MC, Lin JK. Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathway. J Biol Chem. 2004;279(6):4479-89. doi: 10.1074/jbc.M305529200. [PubMed: 14602723].
  • 18. Patel D, Shukla S, Gupta S. Apigenin and cancer chemoprevention: progress, potential and promise (review). Int J Oncol. 2007;30(1):233-45. [PubMed: 17143534].
  • 19. Gates MA, Tworoger SS, Hecht JL, De Vivo I, Rosner B, Hankinson SE. A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer. Int J Cancer. 2007;121(10):2225-32. doi: 10.1002/ijc.22790. [PubMed: 17471564].
  • 20. Shukla S, Mishra A, Fu P, MacLennan GT, Resnick MI, Gupta S. Up-regulation of insulin-like growth factor binding protein-3 by apigenin leads to growth inhibition and apoptosis of 22Rv1 xenograft in athymic nude mice. FASEB J. 2005;19(14):2042-4. doi: 10.1096/fj.05-3740fje. [PubMed: 16230333].
  • 21. Ashkani-Esfahani S, Zarifi F, Asgari Q, Samadnejad AZ, Rafiee S, Noorafshan A. Taurine improves the wound healing process in cutaneous leishmaniasis in mice model, based on stereological parameters. Adv Biomed Res. 2014;3:204. doi: 10.4103/2277-9175.142314. [PubMed: 25337534]. [PubMed Central: PMC4202507].
  • 22. Ponrasu T, Subamekala MK, Ganeshkuma M, Suguna L. Role of Annona squamosa on antioxidants during wound healing in streptozotocin-nicotinamide induced diabetic rats. J Pharm Phytochem. 2013;2(4):77-84.
  • 23. Goodson WH, Hung TK. Studies of wound healing in experimental diabetes mellitus. J Surg Res. 1977;22(3):221-7. [PubMed: 14280].
  • 24. Ponrasu T, Suguna L. Efficacy of Annona squamosa on wound healing in streptozotocin-induced diabetic rats. Int Wound J. 2012;9(6):613-23. doi: 10.1111/j.1742-481X.2011.00924.x. [PubMed: 22233431].
  • 25. Martins MD, Marques MM, Bussadori SK, Martins MA, Pavesi VC, Mesquita-Ferrari RA, et al. Comparative analysis between Chamomilla recutita and corticosteroids on wound healing. An in vitro and in vivo study. Phytother Res. 2009;23(2):274-8. doi: 10.1002/ptr.2612. [PubMed: 18803230].
  • 26. Nayak BS, Raju SS, Rao AV. Wound healing activity of Matricaria recutita L. extract. J Wound Care. 2007;16(7):298-302. doi: 10.12968/jowc.2007.16.7.27061. [PubMed: 17708380].
  • 27. Duarte CM, Quirino MR, Patrocinio MC, Anbinder AL. Effects of Chamomilla recutita (L.) on oral wound healing in rats. Med Oral Patol Oral Cir Bucal. 2011;16(6):e716-21. [PubMed: 21196867].

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