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Trauma Mon. 2012;17(4): 386-388.
doi: 10.5812/traumamon.7099
PMID: 24350133
PMCID: PMC3860668
Scopus id: 84874035676
  Abstract View: 56
  PDF Download: 49

Research Article

Local Erythropoietin Injection in Tibiofibular Fracture Healing

Hooman Bakhshi 1, Gholamhossein Kazemian 1, Mohammad Emami 1, Ali Nemati 1 * , Hossein Karimi Yarandi 1, Farshad Safdari 2

1 Department of Orthopedic Surgery, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
2 Orthopedic Research Center, Akhtar Orthopedic Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
*Corresponding author: Ali Nemati, Department of Orthopedic Surgery, Imam Hossein Hospital, Shahid Madani St, Tehran, IR Iran. Tel/Fax: +98-9133425890, E-mail: Email: ali_nemati802002@yahoo.com.

Abstract

Background: Erythropoietin (EPO), in addition to its function as an erythropoiesis regulator has a regenerative activity on some nonhematopoietic tissues. Animal studies have suggested a role for erythropoietin in bone healing.

Objectives: The present study aimed to evaluate the effects of local EPO injection in healing of tibiofibular fractures.

Materials and Methods: In a prospective double blind study, 60 patients with tibiofibular fracture were divided to equal EPO or placebo groups, randomly. Patients received local injection of either EPO or a placebo to the site of fracture two weeks after surgical fixation. Patients were followed by clinical and radiographic examination to determine the union rate. The period of fracture union and incidence of nonunion were compared between the two groups.

Results: The demographic data and types of fractures were similar in the both groups. The mean duration of the fracture union was 2.1 weeks shorter in those treated with EPO (P = 0.01). Nonunion was observed in 6 patients of the control group and 2 receiving EPO (P = 0.02). No patient experienced any adverse effect from local EPO injections.

Conclusions: EPO injection into the site of tibiofibular fractures may possibly accelerate healing

Keywords: Fractures, Bone, Erythropoietin, Wound Healing

Implication for health policy/practice/research/medical education:

The findings of this study show that injection of erythropoietin in acute tibiofibular fracture is able to accelerate bone healing and diminish the rate of nonunion and delayed union.

Please cite this paper as:

Bakhshi H, Kazemian G, Emami M, Nemati A, Karimi Yarandi H, Safdari F. Local Erythropoietin Injection in Tibiofibular Fracture Healing. Trauma Mon. 2013;17(4):386-8. DOI: 10.5812/traumamon.7099

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Submitted: 04 Jul 2012
Revised: 28 Oct 2012
Accepted: 17 Nov 2012
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