Trauma Mon. 2019;24(3): e79365.
doi: 10.5812/traumamon.79365

Scopus id: 85067230859
  Abstract View: 474
  PDF Download: 499

Research Article

Comparison of Burn Treatment with Nano Silver-Aloe Vera Combination and Silver Sulfadiazine in Animal Models

Seyed Abdollah Mousavi 1, Seyed Jaber Mousavi 2 * , Ali Zamani 3, Seyede Zahra Nourani, Ali Abbasi 5, Ebrahim Nasiri 5, Jason Abbas Aramideh 7

1 Department of Pediatric Surgery, Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran
2 Department of Community Medicine, Mazandaran University of Medical Sciences, Sari, Iran
3 Department of Pharmacology, Tehran University of Medical Sciences, Tehran, Iran
4 Department of Infectious Disease, Zareh Hospital, Mazandaran University of Medical Sciences, Sari, Iran
5 Department of Pathology, Islamic Azad University, Sari, Iran
6 Department of Anesthesiology, Traditional and Complementary Medicine Research Centre, Mazandaran University of Medical Sciences, Sari, Iran
7 Brain and Mind Centre, Sydney Medical School, University of Sydney, Australia
* Corresponding author: MD, Assistant of Professor, Department of Community Medicine, Mazandaran University of Medical Sciences, Farah Abad Road, Sari, Iran. Tel/Fax: +98-1133344506, Email: Email: j_mousavi@mazums.ac.ir


Background: Silver sulfadiazine cream is used extensively for burns, nonetheless, several adverse reactions and side effects are presented in multiple cases. The aim of this study was to compare the healing effect of nano silver-aloe vera composition and silver sulfadiazine on burns in experimental rat models.

Objectives: The experimental study was performed on 15 male Sprague-Dawley rats to compare the burn treatment with nano silveraloe vera combination and silver sulfadiazine in the animal laboratory.

Methods: Two deep second degree burns on both sides of the abdomen were created. One side was covered by cream and the other by 1% silver sulfadiazine. Response to treatment was assessed by digital photography on day 28. Histological parameters, such as angiogenesis, fibrosis, epithelialization, and inflammatory reactions, were evaluated.

Results: The average burn size in the nano silver aloe vera group was significantly lower compared to the average burn size of the silver sulfadiazine group (P < 0.05). Upon pathologic assessment, the re-epithelialization of the epidermis on the fourteenth day in the nano silver group was significantly higher. In addition, this difference in terms of fibrosis and angiogenesis was observed on the fourteenth day and it was higher in the nano silver group (P < 0.05).

Conclusions: The use of nano silver compounds in combination with aloe vera compared to silver sulfadiazine cream can expedite re-epithelialization and wound healing in rats.

Keywords: Aloe Vera, Silver Sulfadiazine, Nano Silver, Burn

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Submitted: 20 May 2018
Revised: 25 Nov 2018
Accepted: 05 Dec 2018
First published online: 12 Mar 2019
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