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Trauma Mon. 2014;19(2): e17196.
doi: 10.5812/traumamon.17196
PMID: 25032151
PMCID: PMC4080617
Scopus id: 84904246880
  Abstract View: 34
  PDF Download: 27

Research Article

Platelet-Rich Plasma in Treatment of Zoledronic Acid-Induced Bisphosphonate-related Osteonecrosis of the Jaws

Farzin Sarkarat 1, Mohammad Hosein Kalantar Motamedi 2,3 * , Jahanfar Jahanbani 4, Dena Sepehri 5, Roozbeh Kahali 1, Zahra Nematollahi 6

1 Department of Oral and Maxillofacial Surgery, Buali Hospital, Azad University of Medical Sciences, Tehran, IR Iran
2 Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
3 Department of Maxillofacial Surgery, Azad University of Medical Sciences, Tehran, IR Iran
4 Department of Oral and Maxillofacial Pathology, Dental Branch, Azad University of Medical Sciences, Tehran, IR Iran
5 Private Practice, Tehran, IR Iran
6 School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
Corresponding author: Mohammad Hosein Kalantar Motamedi, Trauma Research Center, Office of the Editor, Baqiyatallah University of Medical Sciences, Tehran, IR Iran. Tel.: +98- 9121937154, Fax: +98-2188053766 Email: Motamedical@yahoo.com

Abstract

Background: Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a well-known challenging entity warranting management. Platelet-Rich Plasma (PRP) plays an important role in bone biology by enhancing bone repair and regeneration.

Objectives: The aim of this animal study was to evaluate the effects of PRP on zoledronic acid-induced BRONJ.

Materials and Methods: Seven rats were given 0.04 mg Zoledronic acid intravenously once a week for five weeks. Two weeks later, the animals underwent extraction of their first lower molars, bilaterally. After clinical confirmation of the osteonecrosis, PRP was injected randomly into one of the extraction sockets of each rat. Three weeks later, all rats were sacrificed in order to obtain histological sections. The analysis of epithelialization was performed by McNamar’s test, and the analysis of osteogenesis and angiogenesis was performed by the Wilcoxon Sign Rank test. P value was set at 0.05.

Results: We found no significant differences between the two groups regarding the amount of epithelialization, angiogenesis or sequestrum formation (P > 0.05), but a significant difference was seen between the two groups regarding the amount of existing vital bone (P < 0.05).

Conclusions: Our study demonstrates positive results (preservation or regeneration of bone) using PRP in treatment of BRONJ. Although PRP may enhance osseous regeneration, long-term follow-ups are required to confirm its benefits.

Keywords: Zoledronic Acid, Bisphosphonate, Osteonecrosis, Bisphosphonate-Related Osteonecrosis of the Jaw, Osteoporosis, Platelet-Rich Plasma
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Submitted: 27 Dec 2013
Accepted: 27 Jan 2014
First published online: 18 Mar 2014
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